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Morphological features of adenomatous polyps in the human large intestine. (a) “Bottom-up” morphology characterized by ascending cells with nuclear atypia (arrows indicate atypical cells) and normal plateau. (b) “Top-down” morphology with accumulation of atypical cells at the mucosal plateau (arrows indicate atypical cells), but normal cell composition, including goblet cells at the crypt basis. Original magnification: 200×.
