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. 2019 Apr 18;11(4):555. doi: 10.3390/cancers11040555

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Targeting Wnt via Notch in a model of Casp8 deletion. (a) Severe cell death in the large intestinal mucosa of Casp8^f/f villinCre+ mice with deletion in Casp8 in intestinal epithelial cells (Casp8^Δint). Arrows indicate examples of apoptotic bodies. (b) Typical features of normal large intestinal mucosa in Casp8^f/f villinCre- control littermates (Casp8^f/f) with a high number of goblet cells. (c) Restoration of goblet cells in the large intestinal mucosa of Casp8^Δint animals treated with the Notch inhibitor dibenzazepine DBZ. (d) Large intestinal mucosa of Casp8^f/f mice after DBZ treatment with mucostatic features at crypts (arrows). Original magnification: 200×.