AMPK	AMP-activated protein kinase
Apaf-1	protease activating factor-1
Apo2L	Apo-2 ligand
ATG	autophagy-related genes
Bak	Bcl-2 antagonist or killer
Bax	Bcl-2-associated X protein
Bcl-2	B-cell CLL/lymphoma 2
Bcl-xL	B-cell lymphoma-extra-large
BH	Bcl-2 homology
Bid	BH3-only protein
BIR	baculovirus IAP repeat
CLL	chronic lymphocytic leukemia
CTC	circulating tumour cells
c-FLIP	cellular (FADD-like IL-1β-converting enzyme)-inhibitory protein
c-FLIPL	c-FLIP large
c-FLIPS	c-FLIP short
cIAP	cellular inhibitor of apoptosis protein
CPT	circularly permuted TRAIL
DcR	decoy receptor
DD	death domain
DED	death effector domains
DISC	death-inducing signalling complex
DLT	dose-limiting toxicity
DR	death receptor
ERK	extracellular signal-regulated kinases
FADD	Fas-associated death domain
FAP	fibroblast-activation protein
Fc	fragment crystallizable region
FDA	United States Food and Drug Administration
FLICE	FADD-like IL-1β-converting enzyme
FOLFIRI	folinic acid, fluorouracil, irinotecan
GALNT14	polypeptide N-acetylgalactosaminyltransferase 14
GPI	glycosylphosphatidylinositol
HCC	hepatocellular carcinoma
HSA	human serum albumin
HTS	high-throughput screenings
IgG	Immunoglobulin G
IKK	inhibitor of κB kinase
IL	interleukin
iz	isoleucin
IκB	inhibitor of κB
JNK	c-Jun N-terminal kinases
KRAS	Kirsten rat sarcoma
LUBAC	linear ubiquitin chain assembly complex
LZ	leucine zipper
MAPK	mitogen-activated protein kinase
Mcl-1	myeloid leukaemia cell differentiation protein
miRNA	microRNA
MOM	mitochondrial outer membrane
MOMP	mitochondrial outer membrane permeabilization
MPD	membrane-proximal domain
MTD	maximum tolerated dose
mTOR	mechanistic target of rapamycin
NEMO	NF-κB essential modifier
NF-κB	nuclear factor kappa-light-chain-enhancer of activated B cells
NIAP	neuronal apoptosis inhibitory protein
NSCLC	non-small-cell lung cancer
OPG	osteoprotegerin
ORR	objective response rate
OS	overall survival
PFS	progression-free survival
pI	isoelectric point
PI3K	tyrosine kinase Src and phosphoinositide 3-kinase
PUMA	p53 upregulated modulator of apoptosis
Rac1	Ras-related C3 botulinum toxin substrate 1
rhTRAIL	recombinant human TRAIL
RIPK	receptor-interacting protein kinase
RRMM	relapsed refractory multiple myeloma
scTRAIL	single-chain TRAIL
SMAC/DIABLO	second mitochondrial activator of caspases/direct inhibitor of apoptosis-binding protein with low pI
SR	superfamily
tBID	truncated BH3-only protein
TD	thalidomide/dexamethasone
TNF	tumor necrosis factor
TNF-SF	TNF-superfamily
TRAF2	TNF receptor-associated factor-2
TRAE	treatment-related adverse events
TRAIL	TNF-related apoptosis-inducing ligand
TRAIL-R	TRAIL receptor
TRA	TRAIL receptor agonist
Ts-IAP	testis-specific IAP
USP8	ubiquitin-specific peptidase 8
VHH	high-affinity heavy chain domain
XIAP	X-linked inhibitor of apoptosis protein