Table 6.
Fe, Zn, Cu concentrations in kidney cortex and liver, and Ca concentration in femur in the 90-day oral toxicity study of Ca supplementation exposure to 1 mg Cd/Kg diet (Exp 1).
| Parameter (ug/g) | Control | Cd1 | Cd1+CaL | Cd1+CaM | Cd1+CaH |
|---|---|---|---|---|---|
| Fe content in liver | 434.99 ± 99.29 | 494.44 ± 133.35 | 397.39 ± 105.18 | 389.65 ± 56.40 | 277.38 ± 104.47 *,# |
| Fe content in kidney | 467.75 ± 107.84 | 457.65 ± 110.05 | 308.41 ± 65.42 | 302.01 ± 69.40 | 228.00 ± 48.22 *,# |
| Zn content in liver | 40.42 ± 2.88 | 40.38 ± 3.85 | 43.00 ± 6.34 | 39.96 ± 4.88 | 40.34 ± 2.83 |
| Zn content in kidney | 57.56 ± 7.31 | 57.19 ± 7.16 | 54.95 ± 3.82 | 56.42 ± 3.73 | 57.19 ± 9.27 |
| Cu content in liver | 1.09 ± 0.26 | 0.94 ± 0.16 | 1.02 ± 0.34 | 1.19 ± 0.27 | 0.90 ± 0.08 |
| Cu content in kidney | 2.81 ± 0.79 | 2.46 ± 0.82 | 2.70 ± 0.60 | 2.31 ± 0.68 | 2.11 ± 0.76 |
| Ca content in femur | 2503.78 ± 149.36 | 2492.26 ± 210.59 | 2486.75 ± 148.93 | 2470.69 ± 121.19 | 2361.25 ± 196.84 |
Data are mean ± SD (n = 10). * p < 0.05 by ANOVA and Dunnett’s, vs. control; # p < 0.05 by ANOVA and Dunnett’s, vs. Cd1 group. The Control, Cd1, Cd1+CaL, Cd1+CaM, and Cd1+CaH groups respectively represent animals fed with the AIN93G diet without Cd, with 1 mg Cd/kg, with 1 mg Cd/kg plus 0.15% Ca supplementation, with 1 mg Cd/kg plus 0.4% Ca supplementation, and with 1 mg Cd/kg plus 0.6% Ca supplementation.