Figure 6.

Tumor growth inhibition by siOPN NPs in the orthotopic xenograft MDA-MB-231 mammary carcinoma mice model. Targeted vs. non-targeted siOPN NPs were injected at a dose of 1 mg/kg by body weight of siOPN (arrows, (a)). Tumor size is presented as the tumor volume ratio, V/V₀. V and V₀, tumor volume measured at each time point and initial tumor volume (day 1), respectively, (mean ± SEM; n= 5–7 in each group, * p < 0.05, treatment vs. control). Knockdown of OPN mRNA levels evaluated by RT-PCR is shown in (b). OPN mRNA levels were normalized to GAPDH and to untreated control animals (mean ± SEM; n = 5–7 in each group, * p < 0.05, ** p < 0.01, treatment vs. control).