Table 1.

The databases pictured in Figure 2 are briefly described and qualified for their relevance to virology.

Name	URL	Main Content	Relevance to Virology	Example of Use	Data Status	Created in	Reference
ViralZone	viralzone.expasy.org	Illustrated encyclopedia of viruses	Links textbook knowledge to sequence data	Explore the specific molecular biology of a virus	Curated	2008	[17]
UniProt	www.uniprot.org	Integrated knowledge of proteins	Provides protein sequence and functional information.	Find glycosylation sites in protein sequence	Curated (Swiss-Prot section)	1986	[18]
neXtprot	www.nextprot.org	Integrated knowledge of human proteins	Provides detailed functional information on human proteins	Characterize human host surface receptors	Partially curated	2009	[19]
PDBe	www.ebi.ac.uk/pdbe	3D structures of proteins	Structural virology: capsid structures, host–virus interactions.	Examine the 3D structure of a capsid protein	Partially curated	1980	[29]
ChEBI	www.ebi.ac.uk/chebi	Information on chemical compounds	Describes chemical compounds interacting with viruses	Explore the molecule formula of a given compound	Curated	2004	[32]
PubChem	pubchem.ncbi.nlm.nih.gov	Information on chemical compounds and corresponding assays	Collects assays involving chemical compounds interacting with viruses	Find binding assays associated with a virus	Minimally curated	2004	[33]
CAZy	www.cazy.org	Carbohydrate Active Enzymes (CAZymes)	Families of viral CAZymes	Find viral CAZymes and associated Enzyme Nomenclature numbers	Curated	1998	[21]
GlyTouCan	www.glytoucan.org	Glycan 2D structures	Provides information on glycan structure.	Check existence of glycan bound by virus	Not curated	2016	[22]
Rhea	www.rhea.org	Enzymatic reactions	Describes virus specific enzyme reactions	Find substrate and product of CAZyme reaction	Curated	2011	[34]
MatrixDB	matrixdb.univ-lyon1.fr	Extracellular matrix components and interactions	Describes glycosaminoglycans and their interactions	Find interactions involving heparan sulfate	Curated	2008	[24]
SugarBind	sugarbind.expasy.org	Host glycans and pathogen lectins	Describes glycan–virus interactions	Explore pathogen lectins/adhesins binding a glycan motif	Curated	2005	[23]
UniLectin3D	www.unilectin.eu	Carbohydrate-binding proteins (not Ab)	Collects glycan–virus interactions	Inspect atomic details of glycan-haemagglutinin interactions	Curated	2018	[25]
GlyConnect	glyconnect.expasy.org	Integrated knowledge of glycoproteins	Describes glycoproteins	Find sialylated glycans on receptor proteins	Curated	2017	[20]
IMGT	www.imgt.org	Integrated knowledge of immunoglobulins	Collects antibody sequences and structures	Find antiviral antibody sequences	Curated	1989	[26]
IEDB	www.iedb.org	Collected knowledge of antigenic ligands (epitopes)	Collect experimental data characterizing the antigenicity of a virus.	Find viral antigenic peptides	Curated	2003	[27]
DAGR	ccr2.cancer.gov/resources/Cbl/Tools/Antibody	Carbohydrate-binding antibodies	Collects anti-glycan reagents	Find glycan binding motifs of antiviral antibodies	Curated	2016	[28]