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. 2019 Apr 21;11(4):568. doi: 10.3390/cancers11040568

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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TRAIL induces the expression of CXCL5/ENA-78 and IL-6 that cannot be prevented by docetaxel co-treatment. (a) Cytokine arrays of untreated PC3 cells and PC3 cells treated with rTRAIL. The diagram on the right shows the quantification of the factors that were induced by rTRAIL (>50%). (b) CXCL5/ENA-78 ELISA results of supernatants from PC3 cells (u) and PC3 cells treated with increasing concentrations of rTRAIL. (c) IL-6 ELISA results of supernatants from PC3 cells (u) and PC3 cells treated with increasing concentrations of rTRAIL. (d) CXCL5/ENA-78 ELISA results of supernatants from PC3 cells (u) and PC3 cells treated with 1 ng/mL sTRAIL from MSCs. (e) IL-6 ELISA results of supernatants from PC3 cells (u) and PC3 cells treated with 1 ng/mL sTRAIL from MSCs. (f) CXCL5/ENA-78 ELISA results of supernatants from PC3 cells mixed with control transfected CHO cells (CHO-ctrl), PC3 cells mixed with FL-TRAIL expressing CHO cells (CHO-FL) and PC3 cells mixed with sTRAIL expressing CHO cells (CHO-sT). (g) IL-6 ELISA results of supernatants from PC3 cells mixed with control transfected CHO cells (CHO-ctrl), PC3 cells mixed with FL-TRAIL expressing CHO cells (CHO-FL) and PC3 cells mixed with sTRAIL expressing CHO cells (CHO-sT). (h) CXCL5/ENA-78 ELISA results of supernatants from untreated PC3 cells (u), PC3 cells treated with docetaxel, treated with rTRAIL or treated with a mix of docetaxel and rTRAIL. (i) IL-6 ELISA results of supernatants from untreated PC3 cells (u), PC3 cells treated with docetaxel, treated with rTRAIL or treated with a mix of docetaxel and rTRAIL. (j) CXCL5/ENA-78 ELISA results of supernatants from untreated PC3 cells (u), PC3 cells treated with docetaxel, treated with sTRAIL from MSCs or treated with a mix of docetaxel and sTRAIL. sTRAIL was used at 1 ng/mL, docetaxel was used at 12.5 nM. (k) IL-6 ELISA results of supernatants from untreated PC3 cells (u), PC3 cells treated with docetaxel, treated with sTRAIL or treated with a mix of docetaxel and sTRAIL. sTRAIL was used at 1 ng/mL, docetaxel was used at 12.5 nM. Values represent mean ± SE.