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. 2019 Mar 28;11(4):437. doi: 10.3390/cancers11040437

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Flow cytometric analysis of Annexin V/PI stained cells after MG3 and CDDP treatments for 24 h on (A) A549 and (B) H1975 cells. Western blot analysis of apoptotic markers, caspase-3 and PARP, for (C) A549 and (D) H1975 cells. Inhibition of MG3-induced apoptosis by the pan caspase inhibitor Z-VAD(OMe)-FMK in (E) A549 and (F) H1975 cells. Data are expressed as mean ± SEM (n = 3). * p ≤ 0.05, ** p ≤ 0.01, and *** p ≤ 0.001 vs. control. ^@ p ≤ 0.05, ^@@ p ≤ 0.01, and ^@@@ p ≤ 0.001 vs. MG3. ^# p ≤ 0.05, ^## p ≤ 0.01, and ^### p ≤ 0.001 vs. CDDP.