Table 3.
Associations between offspring intake of iron droplets during first 18 months of life in relation to later risk of type 1 diabetes.
| No. Cases (%)/N | Unadjusted | Adjusted 1 1 | Adjusted 2 2 | |
|---|---|---|---|---|
| Offspring use of iron droplets reported at 18 months (n = 51,859) | ||||
| No | 104 (0.43%)/24,272 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Yes | 87 (0.32%)/27,587 | 0.73 (0.55, 0.97) | 0.74 (0.55, 1.00) | 0.73 (0.55, 0.99) |
| No | 104 (0.43%)/24,272 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| 1–6 months | 82 (0.32%)/25,483 | 0.75 (0.56, 1.00) | 0.76 (0.56, 1.02) | 0.75 (0.55, 1.01) |
| >6 months | 5 (0.24%)/2104 | 0.56 (0.28, 1.37) | 0.55 (0.23, 1.35) | 0.56 (0.23, 1.36) |
| p-value for trend 3 | 0.03 | 0.03 | 0.03 | |
| p-value for effect 4 | 0.08 | 0.10 | 0.09 | |
Number and percentage of cases are depicted in bold. 1 Adjusted for parental socio-economic status, mode of delivery, pre-pregnancy BMI, age, smoking status, parity, gestational age, maternal age, and breastfeeding. 2 Same as model 1 but in addition adjustments are made for maternal celiac disease, maternal type I diabetes and maternal anemia. 3 Chi-square-test is used to test for a linear dose-response—the iron variable is included in the regression model as a continuous (three values) variable. 4 Chi-square-test is used to test the null hypothesis that all three groups are equal.