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. 2019 Apr 6;11(4):796. doi: 10.3390/nu11040796

Figure 1.

Figure 1

Phaeodactylum tricornutum ethanolic extract (PTE) ameliorates fat deposition in C57BL/6J mice fed with a high fat diet (HFD). Evolution of body weight (bw) gain (A), cumulative energy intake from food (B), and body composition (C) from day 1 to 26 of dietary challenge. Body weight lost upon a 6 h fast, on day 22 (D). Liver, interscapular brown adipose tissue (BAT), and inguinal, epididymal, and retroperitoneal white adipose tissue (iWAT, eWAT, and rWAT) weights (E), adiposity as eWAT weight as percent body weight (F), and mRNA expression levels of Mest in iWAT, eWAT, and BAT (G) at the end of the experiment. HFD-fed mice received daily an oral dose of PTE (100 mg or 300 mg/kg bw) or placebo (olive oil:water, 2:1, v:v) for 26 days. Data are mean ± SEM of 5–6 male mice/group. To compare between two groups, the non-parametric Mann–Whitney U test was used: *, different (p < 0.05) from vehicle; and #, different (p < 0.05) between doses.