Table 2.

Major miRNAs involved in EMT of TNBC.

miRNAs	Targets and Pathways	Sense of Dyregulation in TNBC	Role of miRNA in TNBC	References
miR-31		Downregulated	Anti-tumoural	[46]
DLK1-DIO3 region (miRs 300, 382, 494, 495, 539, 543, and 544)	TWIST1, BMI1, ZEB1/2, and miR-200 family	Downregulated	Anti-tumoural	[61]
miR200a	ZEB1, ZEB2 and SUZ12 E-cadherin pathway EPH receptor A2 (EPHA2) EPHA2 pathway	Downregulated	Anti-tumoural	[62]
miR200b	PKCα/Rac1	Downregulated	Anti-tumoural	[63]
miR-200c	ZEB1	Downregulated	Anti-tumoural	[64]
miR-30a	Inhibition of ROR1	Downregulated	Anti-tumoural	[65]
miR-146a	Inhibition of RhoA	Downregulated	Anti-tumoural	[66]
miR-143-3p	LIMK1 expression LIMK1/CFL1 pathway	Downregulated	Anti-tumoural	[67]
miR-200b-3p/miR-429-5p	LIMK1 expression LIMK1/CFL1 pathway	Downregulated	Anti-tumoural	[68]
miR-139-5p	TGF-β, Wnt, MAPK, and PI3K	Downregulated	Anti-tumoural	[69]
miR-212-5p	Prrx2 Wnt/β-catenin pathway	Downregulated	Anti-tumoural	[70]
miR-199a-5p		Downregulated	Anti-tumoural	[71]
miR-155		Downregulated	Anti-tumoural	[72]
miR-34c-3p	MAP3K2 MAP3K2 pathway	Downregulated	Anti-tumoural	[73]
miR-3178	Notch1	Downregulated	Anti-tumoural	[74]
miR-200b-3p		Downregulated	Anti-tumoural	[75]
miR-125b	MAP2K7 MAPK pathway	Downregulated	Anti-tumoural	[76]
miR-655	Prrx1	Downregulated	Anti-tumoural	[77]
miR27-a	PTEN, PKB PI3K/AKT pathway	Up-regulated	Pro-tumoural	[78]
miR-182	Inhibition of FOXF2 PFN1	Up-regulated Up-regulated	Pro-tumoural Pro-tumoural	[79] [80]
miR-454	PTEN PI3K/AKT pathway	Up-regulated	Pro-tumoural	[81]
miR-373	HIF1α and TWIST HIF1α-TWIST pathway	Up-regulated	Pro-tumoural	[82]
miR-221/222	ADIPOR1 and TRPS1 NF-κB, IL6, and JAK2/STAT3 pathway	Up-regulated	Pro-tumoural	[83]
miR-10b	TGF-β1-induced EMT pathway	Up-regulated	Pro-tumoural	[84]