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. 2019 Apr 19;17(4):235. doi: 10.3390/md17040235

Figure 4.

Figure 4

Effect of C-PC on Bax-mediated apoptosis caused by cisplatin. (A) Western blot showing Bax expression, compared with β-actin as the loading control (n = 3 per lane). (B) Western blot showing Bcl-2 expression, compared with β-actin as the loading control (n = 3 per lane). (C) Relative changes in the Bax/Bcl-2 expression ratio. CP treatment upregulated Bax expression compared with that in the control cells, and pretreatment with C-PC significantly alleviated the CP-induced increase in Bax expression. CP treatment downregulated Bcl-2 expression, and C-PC pretreatment alleviated the CP-induced downregulation of Bcl-2 expression. Cells were incubated with 1 μg/mL C-PC for 1 h and/or 30 μM CP for 24 h. Data are shown as the mean ± standard deviation; * p < 0.05, compared with the cells treated with CP alone. C-PC, C-phycocyanin; CP, cisplatin.