Figure 6.

The apoptotic mechanism of the combinatorial treatment of luteolin and oxaliplatin. Both luteolin-induced apoptosis and oxaliplatin-induced cell cycle arrest in HCT116 human colorectal cancer cells were dependent on p53 function. Luteolin-induced apoptosis might override the oxaliplatin-induced cell cycle arrest, possibly through the increased HO-1 expression in p53-expressing cells. In addition, luteolin-induced p53-null HCT116 cell death could be intensified by oxaliplatin treatment through an unknown mechanism(s).