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. 2019 Apr 15;11(4):542. doi: 10.3390/cancers11040542

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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TPC1 mediates FBS-induced lysosomal Ca²⁺ release and proliferation in mCRC cells. (A) 20% FBS induced an intracellular Ca²⁺ transient that was significantly reduced by NED-19 (100 μM, 30 min) and by deleting TPC1 with the specific siTPC1. (B) mean ± SE of the percentage of responding cells under the designated treatments. The asterisk indicates p < 0.05. (C) mean ± SE of the amplitude of the peak Ca²⁺ response to NAADP under the designated treatments. The asterisk indicates p < 0.05. (D) mean ± SE of the percentage of 20% FBS-induced cell proliferation under control conditions and upon pharmacological (NED-19) and genetic (siTPC1) blockade of NAADP-induced Ca²⁺ release. The asterisk indicates p < 0.05.