. 2019 Mar 27;11(4):434. doi: 10.3390/cancers11040434

Table 2.

CTCs contribute to metastasis.

Tumor ¹	CTC ²	Outcome ³	Metastasis ⁴	Ref.
BC	EpCAM⁺CD44⁺CD47⁺MET⁺	OS ⁶	NSG mice; bone mets ⁵	[126]
BC	EpCAM⁻HER2⁺EGFR⁺HPSE⁺NOTCH1⁺	NA ⁷	Nude mice; lung met ⁸, brain met ⁹	[127]
CRC	CTC lines with CSC properties	NA ⁷	Nude mice; lung and liver met ¹⁰	[128]
PC	CK⁺Vimentin⁺CD45⁻	Met ¹¹	NA ⁷	[100]

¹ BC: breast cancer, CRC: colorectal cancer, PC: prostate cancer; ² CTC types; ³ clinical outcome; ⁴ mouse model; ⁵ femoral medullar cavity implantation; ⁶ reductions in overall survival; ⁷ not available; ⁸ tail vein injection; ⁹ intracardiac injection; ¹⁰ spleen injection; ¹¹ association with metastasis.