Figure 2.

Clinical factors associated with the development of broadly neutralizing antibody responses in men and women in the MSM and IDU Amsterdam Cohort. Comparison between MSM, male IDUs and female IDUs for (A) viral load in plasma at setpoint and (B) CD4+ T cell counts at setpoint. Each data point represents one individual. Statistically significant differences between the different groups were determined using a Mann–Whitney t-test and the P-values are shown; ns, not significant. Horizontal bars represent the median value per group. (C) Early sequence env diversity is shown in substitutions/nucleotides (s/nt) for five IDU male versus eight MSM infected individuals. env sequences were obtained within the first three months post-SC. Each dot represents one individual and horizontal bars represent the median diversity per group.