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. 2019 Apr 6;11(4):491. doi: 10.3390/cancers11040491

Figure 3.

Figure 3

Nano-engineered MSCs were more effective in inhibiting orthotopic tumor growth and increased the overall survival of tumor bearing mice. (A) SCID beige mice bearing orthotopic A549 lung tumors were intravenously injected with Dulbecco’s phosphate buffered saline (Saline); 4 Million MSCs engineered with TAT NP (MSCs + TAT NP); PTX solution; TAT PTX NP; 4 Million MSCs engineered with TAT PTX NP (MSCs + TAT PTX NP). Plot of normalized bioluminescence readings (n = 10 for MSCs + TAT PTX NP and n = 8 for all other groups). Arrowheads indicate injection days. (*) Indicates significantly different (p < 0.05) from PTX solution; # indicates significantly different (p < 0.05) from TAT PTX NP. (B) Kaplan–Meier survival curves for the different treatment groups. Log rank test of MSCs + TAT PTX NP and control groups yields p < 0.0001 (*).