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The role of autophagy in endothelial cells maintenance. Autophagy plays an important role in the regulation of the Sinusoidal endothelial liver cells (SEC) phenotype. In fact, under basal conditions, autophagy maintains SEC homeostasis. During liver injury, autophagy impairment increases oxidative stress and leads to liver fibrosis. On the other hand, a high autophagy rate induces caveolin-1 degradation, thus leading to SEC defenestration and liver fibrosis.
