Table 3.

Comparison of p-values obtained with one-way ANOVA with one group factor (karyotype) at three levels (XX, XXY, XY), and p-values obtained with one–way ANCOVA with estradiol and testosterone as covariates, performed on the levels of cytokines secreted by purified monocytes after stimulation with LPS, resiquimod, and zymosan.

		ANOVA with one factor (karyotype)			ANCOVA with two covariates (steroids)
		XX vs. XY	XX vs. XXY	XY vs. XXY	XX vs. XY	XX vs. XXY	XY vs. XXY
LPS	IL-10	0.076	<0.001	0.012	0.231	0.001	0.084
	IL-8	0.036	0.002	0.499	0.939	0.147	0.162
	IL-6	0.003	0.001	0.292	0.024	<0.001	0.903
	IL-1β	ANOVA not significant (p = 0.123)			0.07	0.033	0.372
	TNF-α	0.003	0.001	0.875	0.011	0.001	0.469
Resiquimod	IL-10	Not detectable			Not detectable
	IL-8	0.007	<0.001	0.013	0.024	<0.001	0.375
	IL-6	0.001	<0.001	0.079	0.253	0.001	0.095
	IL-1β	0.003	0.004	0.45	0.025	0.001	0.862
	TNF-α	0.006	<0.001	0.084	0.18	0.002	0.246
Zymosan	IL-10	0.253	<0.001	<0.001	0.844	0.001	0.001
	IL-8	0.037	<0.001	0.022	0.014	<0.001	0.674
	IL-6	0.003	<0.001	0.262	0.006	<0.001	0.774
	IL-1β	ANOVA not significant (p = 0.064)			0.368	0.08	0.758
	TNF-α	0.012	<0.001	0.49	0.003	<0.001	0.506