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. 2019 Apr 25;11(4):237. doi: 10.3390/toxins11040237

Figure 2.

Figure 2

(A) The effect of carboplatin and palmatine (each 10 µM) on the caspase 3/7 activity at 48 h in OVCAR-4 cells. The caspase activity was measured and normalized with corresponding sulforhodamine B (SRB)-stained cells to estimate the surviving cell number. **** denotes that the result is significantly different (p < 0.001). The results were expressed as mean ±SEM, n = 3. (B) Detection of poly-ADP-ribose polymerase (PARP) cleavage by immunoblotting. OVCAR-4 cells were treated with palmatine (10 or 20 µM) and carboplatin (40 µM) for 48 h. The vehicle-treated cells served as the control.