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. 2019 Mar 29;11(4):444. doi: 10.3390/cancers11040444

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Structure of (TNF)-related apoptosis-inducing ligand (TRAIL) and DR5. (A) Structure of the TRAIL trimer. Left panel corresponds to the side view and right panel to the down view. Yellow sphere corresponds to a Zinc ion. (B) Structure of the DR5 (TRAIL-R2) monomer anchored to cell surface. CRD (cystein rich domain). DD (death domain). (C) TRAIL-DR5 complex. The TRAIL trimer is drawn as tubes rendering in gradations of green, and the three receptor molecules are rendered as tubes in gradations of purple.