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. 2019 Mar 29;11(4):444. doi: 10.3390/cancers11040444

Figure 2.

Figure 2

Proposed models for the function of the pre-ligand binding domain (PLAD). (A) Model of “conformational change”. In this model, receptors form trimers due to the PLAD, and conformational changes upon TRAIL binding allow juxtaposition of intracellular death domains (DD) of DR4/DR5 receptor molecules. (B) Mode of “induction of super-clustering”. In this model, PLAD allows the formation of receptor dimers, and binding of TRAIL promotes a cooperative recruitment of receptors allowing a supra-molecular clustering.