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Proposed model of cooperation of TRAIL and anti-DR5 monoclonal antibody to promote receptor clustering. (A) View of three TRAIL-anti-DR5 monoclonal antibody ternary complexes (down view). (B) Proposed “honeycomb” model of higher order clustering induced by multiple ternary complexes. Green dots correspond to TRAIL bound to three DR5 receptors (purple). Light brown lines correspond to anti-DR5 monoclonal antibody Fab fragments expanding from DR5.
