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. 2019 May 9;11:108. doi: 10.3389/fnagi.2019.00108

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Copyright © 2019 Cao, Guan, Liang, Huang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression of EPs is upregulated in APP/PS1 Tg mice. (A–F) The brains of 9-month-old APP/PS1 Tg mice were collected after anesthesia and perfusion (n = 6). (A,B) The mRNA and protein expression levels of EP1-4 were determined by qRT-PCR and western blotting, respectively. β-actin and GAPDH served as the internal controls. (C–F) The morphology of EP1-4 was determined by immunohistochemistry. The scale bar represents 400 or 100 μm. These images are representative of six independent mouse experiments. The data represent the means ± S.E. of independent experiments. ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001 with respect to the WT mice.