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. 2019 May 9;10:485. doi: 10.3389/fphar.2019.00485

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Copyright © 2019 Zhang, Deng, Jiang, Cai, Liu, Zhang, Tan, Huang, Jin, Liu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ATRA suppressed mTOR signaling pathway. (A) A7r5 and HASMC cells were incubated with the indicated doses (1, 2 as well as 4 μM) of ATRA for 6 h, (B) levels of p-mTOR, mTOR, p-p70S6K as well as p-4EBP1 were tested via western blotting. (C) Relative expression levels of p-mTOR and total-mTOR. (D) Relative expression level of p-p70S6K (n = 3). (E) Relative expression level of p-4EBP1 (n = 3). Data are shown as mean ± SD. ^∗p < 0.05, ^∗∗p < 0.01 compared with the Control group.