Table 2.

Effect of rosmarinic acid and sinapic acid on the superoxide dismutase (SOD) and catalase (CAT) activities in the lenses of ovariectomized rats.

Parameter/Group	SHAM	OVX	OVX + ESTR	OVX + RA10	OVX + RA50	OVX + SA5	OVX + SA25
SOD (U/mg of protein)	0.194 ± 0.017	0.156 ± 0.003	0.170 ± 0.007	0.164 ± 0.005	0.174 ± 0.006	0.171 ± 0.012	0.167 ± 0.002
CAT (nmol/min/mg of protein)	0.085 ± 0.012	0.033 ± 0.009	0.052 ± 0.014	0.075 ± 0.014	0.076 ± 0.020	0.060 ± 0.018	0.063 ± 0.010

Rosmarinic acid at doses of 10 mg/kg (OVX + RA10) and 50 mg/kg (OVX + RA50), sinapic acid at doses of 5 mg/kg (OVX + SA5) and 25 mg/kg (OVX + SA25) or estradiol at a dose 0.2 mg/kg (OVX + ESTR) were administered orally to ovariectomized rats, once daily for 28 days. SHAM: sham-operated control rats; OVX: ovariectomized control rats; SOD: superoxide dismutase (1 U of SOD determines the amount of enzyme required to exhibit 50% dismutation of the superoxide radical); CAT: catalase. Results are presented as the mean ± SEM. No statistically significant differences in results for SOD and CAT were demonstrated by ANOVA.