Table 2.

Summary of the 28 cases of post orthohantivurs panhypopituitarism reported in literature. NE-IFAT: nephropathia epidemica indirect immunofluorescence assay test.

Serotype	Country	No.	Diagnostics	Endocrine Disturbances	Time to Detection	Duration	Outcome	Ref
Puumala	Finland	1	NE-IFAT titre	Panhypopituarism	5 years	NR	Survived	Forslund et al., 1992 [38]
Puumala	Sweden	1	Specific Puumala IgM and IgG	Panhypopituitarism	6 months	NR	Survived	Settergen et al., 1992 [40]
NR	Korea	1	Serologic antibody testing	Panhypopituitarism	Day 20 a	NR	Survived	Suh et al., 1994 [37]
Puumala	Finland	4	NR	NR	-	-	Deceased	Valtonen et al., 1995 b [9]
NR	Korea	1	NR	Panhypopituitarism	13 years	NR	Survived	Kim et al., 2001 [41]
Puumala b Puumala Puumala	Finland Finland Finland	1 1 1	Serologic antibody testing Serologic antibody testing Serologic antibody testing	NR Panhypopituitarism Panhypopituitarism	- 5 months Day 7 a	- NR NR	Deceased Survived Survived	Hautala et al., 2002 [44]
NR Puumala Puumala	Serbia Serbia Serbia	1 1 1	Serologic antibody testing Serologic antibody testing Serologic antibody testing	Panhypopituitarism Panhypopituitarism ACTH, FSH, LH and GH	1.5 years 2 years 2 years	NR NR NR	Survived Survived Survived	Pekic et al., 2005 [42]
NR NR NR NR	Serbia Serbia Serbia Serbia	3 2 1 5	Indirect immunofluorescent assay Indirect immunofluorescent assay Indirect immunofluorescent assay Indirect immunofluorescent assay	GH FSH, LH ACTH ≥4 axes	>6 months >6 months >6 months 0.5–11 yrs	NR NR NR NR	Survived Survived Survived Survived	Stojanovic et al., 2008 [42]
Puumala	Austria	1	Specific Puumala IgM	Panhypopituitarism	Acute a	5 months	Survived	Jost et al., 2009 [39]
Dobrova	Turkey	1	Serologic antibody testing	Panhypopituitarism	Day 19 a	16 months	Survived	Sariguzel et al., 2010 [36]
Puumala	Finland	1	Specific Puumala IgM and IgG	TSH, FSH, LH, ADH	6 months	Ongoing	Survived	Tarvainen et al., 2016 [17]

^a Hormonal disturbances detected during acute infection; ^b Post-mortem study revealing pituitary hemorrhage. NR: not reported.