Table 2.
Clinical characteristics of participants genotyped using Axiom and MEGA arrays (stage 1b and 1c)
| WFSM-Axiom | WFSM-MEGA | ||||||
|---|---|---|---|---|---|---|---|
| T2D-ESKD | Non-diabetic non-nephropathy | T2D-lacking nephropathy | T2D-ESKD | Non-diabetic non-nephropathy | T2D-lacking nephropathy | Non-diabetic ESKD | |
| N | 1700 | 770 | 663 | 219 | 908 | 201 | 1910 |
| Females (%) | 56 | 49 | 64 | 49 | 59 | 62 | 41 |
| Age (years) | 62.0 ± 10.8 | 47.9 ± 12.0 | 55.7 ± 11.6 | 62.0 ± 11.0 | 44.8 ± 13.9 | 55.8 ± 9.5 | 55.4 ± 14.4 |
| Age of onset of diabetes (years) | 39.7 ± 12.8 | – | 46.2 ± 12.3 | 37.8 ± 9.6 | – | 43.7 ± 10.3 | – |
| Duration of diabetes prior to ESKD (years) | 19.1 ± 10.0 | – | – | 20.4 ± 9.5 | – | – | – |
| Duration of ESKD (years) | 3.6 ± 3.6 | – | – | 4.1 ± 3.1 | – | – | 6.2 ± 5.8 |
| Fasting serum glucose (mg/dl) | 184 ± 89 | 96 ± 22 | 163 ± 92 | 127 ± 33 | 96 ± 11 | 174 ± 62 | 90 ± 3 |
| eGFR (ml/min/1.73m2) | – | 96.0 ± 20.8 | 91.3 ± 19.7 | – | 85.9 ± 17.3 | 95.2 ± 17.3 | – |
| Body mass index (kg/m2) | 30.7 ± 7.1 | 29.6 ± 7.4 | 33.1 ± 7.8 | 30.8 ± 7.0 | 29.7 ± 6.6 | 33.0 ± 6.5 | 27.8 ± 7.2 |
Categorical data expressed as percentage; continuous data as mean ± SD
Abbreviations: T2D type 2 diabetes, ESKD end-stage kidney disease, N number, eGFR estimated glomerular filtration rate