Table 1.
Overview of primary and secondary bile acids. VMH Virtual Metabolic Human database (https://vmh.life) [16]. AGORA, a compendium of 818 curated genome-scale gut microbial metabolic reconstructions used in this study.
| Name | Abbreviation | VMH ID | Type | Producer |
|---|---|---|---|---|
| Taurocholate | Tauro-CA | tchola | Primary/conjugated | Human |
| Glycocholate | Glyco-CA | gchola | ||
| Taurochenodeoxycholate | Tauro-CDCA | tdchola | ||
| Glycochenodeoxycholate | Glyco-CDCA | dgchol | ||
| Cholate | CA | cholate | Primary/unconjugated | Human; released by 185/818 AGORA strains |
| Chenodeoxycholate | CDCA | C02528 | ||
| 12-dehydrocholate | 12-dehydro-CA | 12dhchol | Secondary | 38/818 AGORA strains |
| 7-ketodeoxycholate | 7-keto-CA | 7ocholate | 41/818 AGORA strains | |
| 7-dehydrochenodeoxy-cholate | 7-dehydro-CDCA | 7dhcdchol | ||
| 3-dehydrocholate | 3-dehydro-CA | 3dhchol | 16/818 AGORA strains | |
| 3-dehydrochenodeoxy-cholate | 3-dehydro-CDCA | 3dhcdchol | ||
| Isocholate | Iso-CA | isochol | 11/818 AGORA strains | |
| Isochenodeoxycholate | Iso-CDCA | icdchol | ||
| Lithocholate | LCA | HC02191 | 5/818 AGORA strains | |
| Deoxycholate | DCA | dchac | ||
| Allolithocholate | allo-LCA | alchac | ||
| Allodeoxycholate | allo-DCA | adchac | ||
| Ursocholate | UCA | uchol | 3/818 AGORA strains | |
| Ursodeoxycholate | UDCA | HC02194 |