Fig. 3.

A circadian interactome assists rhythmic gene expression. a Cyclic expression of circadian genes such as Dbp and Ash1l is physically coupled in a nuclear environment enriched for actively transcribed genes and E-box DNA elements, coincident with the presence of clock-specific transcription factories. b When clock-controlled genes become silent during the circadian cycle, their physical distances in the nucleus increase, hence losing contact. The circadian interactome is directed by the clock machinery and depends on a functional BMAL1 [61]