Table 2.
Patients’ endothelial biomarkers in the first 3 days
| Biomarker | All Patients (n = 23) | Non-Survivors (n = 10) | Survivors (n = 13) | P value |
|---|---|---|---|---|
| Thrombomodulin (ng/mL) | ||||
| Day 0 | 5.9 (2.4) | 6.3 (1.9) | 5.6 (1.8) | 0.420 |
| Day 1 | 6.3 (1.9) | 6.0 (1.9) | 6.7 (1.6) | 0.535 |
| Day 2 | 7.5 (2.7) | 6.8 (3.0) | 7.5 (2.2) | 0.215 |
| Angiopoietin-1 (ng/mL) | ||||
| Day 0 | 29.0 (16.1) | 30.8 (13.0) | 22.1 (18.7) | 0.203 |
| Day 1 | 24.9 (17.1) | 24.2 (8.8) | 26.2 (15.8) | 0.107 |
| Day 2 | 20.7 (13.8) | 20.1 (6.6) | 22.2 (9.5) | 0.172 |
| Angiopoietin-2 (ng/mL) | ||||
| Day 0 | 19.2 (24.8) | 24.4 (58.2) | 15.7 (23.2) | 0.035 |
| Day 1 | 24.7 (35.3) | 25.6 (29.0) | 17.7 (26.6) | 0.137 |
| Day 2 | 22.7 (15.4) | 23.7 (14.7) | 20.3 (9.2) | 0.577 |
| VEGF (pg/mL) | ||||
| Day 0 | 8.5 (13.7) | 15.3 (32.4) | 7.9 (2.1) | 0.071 |
| Day 1 | 33.0 (65.0) | 24.2 (37.6) | 35.6 (58.1) | 0.438 |
| Day 2 | 62.1 (119.2) | 24.2 (33.9) | 119.9 (105.8) | 0.005 |
| Ang-2/Ang-1 ratio | ||||
| Day 0 | 0.82 (1.82) | 0.90 (1.53) | 0.71 (2.20) | 0.470 |
| Day 1 | 1.01 (1.74) | 1.01 (3.67) | 0.79 (1.95) | 0.342 |
| Day 2 | 1.09 (0.64) | 1.10 (0.21) | 1.02 (1.54) | 0.763 |
Data were presented median (interquartile); VEGF vascular endothelial growth factor, Ang angiopoietin