. Author manuscript; available in PMC: 2019 May 16.

Published in final edited form as: SLAS Discov. 2017 Jan 31;22(6):706–719. doi: 10.1177/2472555216687525

Table 1.

Compounds Classified as Potential Heat Shock Modulators.^a

NSC No.	Name	Yeast 384 Halo Screen EC₅₀
103353	3,5 dipyridin-4-yl-l,2,4-thiadiazole	Not screened
126224	Dimethyl 2-[(2-nitrophenyl)methylidene]propanedioate	Not screened
42199	Benztropine mesylate	No activity
624358	Tricyclo[4.4.0.0(2,7)]decane-5-one, 4,4-dibromo-2-methyl-	2.78 μM in S. cerevisiae and 0.68 μM in S. pombe
145366	2-Propanol, 1,1′-[(l-methylethylidene)bis(4,1-phenyleneoxy)]bis[3-[(1,1,3,3-tetramethylbutyl)amino]-,dihydrochloride	No activity
210236	Crassin	No activity
226080	Rapamycin	2.78 μM in S. cerevisiae and no activity in S. pombe
330500	Macbecin 11	No activity
690634	N,N’-bis(1-nitroacridin-9-yl)propane-1,3-diamine	No activity

List of hit compounds with NSC number and comparison with activity observed in the yeast halo-based assay.^6,7 Only two of seven compounds that were screened in the yeast halo assay had any activity.