FIGURE 1.

The mechanism of insulin resistance and hypoglycaemia on pathology of neurons in AD. A flowchart of key events occurring in the development of AD which includes metabolic syndrome or disease susceptibility to neurodegeneration which results in impaired insulin signaling and hypoglycaemia leading to reduced O-GlcNAcylation of several proteins including APP and Tau. This results in the production of toxic Aβ aggregation and neurofibrillary tangles leading in neuronal death. Thiamet G by inhibition of OGA increases O-GlcNAcylation thus blocking downstream pathological events of AD.