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. 2019 May 9;9:369. doi: 10.3389/fonc.2019.00369

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Copyright © 2019 Rong, Li, He, Liu, Ren, Gao, Mu, Guan, Duan, Zhang, Zhang, Li, Deng and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FTO was downregulated in intrahepatic cholangiocarcinoma. (A) Representative IHC staining of FTO in human ICC specimens. Black arrow indicates intrahepatic bile duct epithelial cells and red arrow indicates ICC cells. (B) Statistical analysis of FTO expression in ICC cases (n = 137) and human paracancerous intrahepatic biliary epithelial cells (para-HIBECS, n = 136). (C) Analysis of FTO expression between ICC cases and paired para-HIBECS (n = 133). (D) Comparison of FTO expression in the cases of recurrence (n = 77) with that of specimens from patients without recurrence (n = 6 1). (E) Differential expression of FTO between poorly-differentiated cases (n = 50) and highly differentiated cases (n = 85).