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. 2019 May 9;9:369. doi: 10.3389/fonc.2019.00369

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Copyright © 2019 Rong, Li, He, Liu, Ren, Gao, Mu, Guan, Duan, Zhang, Zhang, Li, Deng and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FTO promoted cisplatin-induced apoptosis of ICC cells. (A,B) Clonogenic survival assay of shFTO TFK1 cells and corresponding control cells treated with 0, 10, and 20 μM cisplatin. Data are presented as mean ± SD from n = 4. (C) The effects of FTO knockdown on the apoptosis of TFK1 cells treated with cisplatin (CIS, 30 ng/ml, 24 h) were examined using flow cytometric analysis. (D) The statistical analysis for (C). Data are presented as mean ± SD from n = 3. (E) The effects of FTO over-expression on the apoptosis of TFK1 cells treated with cisplatin (CIS, 30 ng/ml, 24 h) were examined using flow cytometric analysis. (F) The statistical analysis for (E), data are presented as mean ± SD from n = 3.