Figure 1.

General performance in touchscreen protocol by phase. Number of sessions at 6 (A) and 9 months (B) during the shaping and the visual discrimination (VD) phase were similar in APPPS1-21 (white bars) and wild-type controls (black bars). However, during reversal learning (REV) APPPS1-21 mice performed worse, indicated by a significantly higher number of sessions required to reach criterion performance. During VD, the total number of learning units (RT + CT) needed to reach criterion performance did not differ between genotypes at 6 (C) and 9 (D) months. However, during reversal learning, APPPS1-21 mice at both ages needed significantly more learning units to reach criterion. Data plotted as mean ± standard error of mean (SEM), *p < 0.05, **p < 0.01, ***p < 0.001 (Bonferroni post hoc test).