Table 1.
Characteristics of the included studies
| Author (year) | Design | Population | Number of subjects | Mean age (years) | Male (%) | Mean BMI (kg/m2) | Dose (mg/d) | Duration (weeks) | Adiponectin measurement | Drop-out (%) |
|---|---|---|---|---|---|---|---|---|---|---|
| Gannagé-Yared et al (2005)18 | R, DB, PC | Non-DM subjects | 40 | 48.8 | 55.0 | 26.4 | 40 | 12 | RIA | 0 |
| Trøseid et al (2005)19 | R, OL | MetS patients | 31 | 47.0 | 100.0 | 32.0 | 40 | 12 | RIA | 3 |
| Sugiyama et al (2007)20 | R, OL | CAD patients with IGT | 40 | 67.0 | 70.0 | 23.5 | 20 | 24 | ELISA | 0 |
| Takagi et al (2008)21 | R, DB, PC | HL patients | 152 | 55.0 | 100.0 | 25.4 | 40 | 48 | ELISA | 0 |
| Koh et al (2009)22 | R, SB, PC | HC patients | 84 | 57.5 | 36.9 | 25.0 | 40 | 8 | ELISA | 2 |
| Kim et al (2013)23 – 20 mga | R, DB, PC | T2DM patients | 38 | 59.2 | 0 | 26.1 | 20 | 16 | ELISA | 7 |
| Kim et al (2013)23 – 40 mga | R, DB, PC | T2DM patients | 35 | 59.1 | 0 | 26.1 | 40 | 16 | ELISA | 7 |
| Koh et al (2013)24 | R, SB, PC, CO | HC patients | 48 | 56.0 | 60.4 | 25.5 | 40 | 8 | ELISA | 6 |
| Koh et al (2013)25 | R, SB, PC | HC patients | 79 | 54.7 | 40.6 | 23.9 | 40 | 8 | ELISA | 3 |
Note:
a
The study by Kim et al (2013) included two pravastatin treatment arms with dosages of 20 and 40 mg/day, respectively, and both the comparisons were included separately.
Abbreviations: BMI, body mass index; CAD, coronary artery disease; CO, crossover; DB, double-blinded; DM, diabetes mellitus; HC, hypercholesterolemic; HL, hyperlipidemic; IGT, impaired glucose tolerance; MetS, metabolic syndrome; OL, open label; PC, placebo-controlled; R, random; RIA, radioimmunoassay; SB, single-blinded; T2DM, type 2 diabetes mellitus.