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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: J Invest Dermatol. 2018 Mar 9;138(9):1945–1954. doi: 10.1016/j.jid.2018.02.035

Figure 4: Reactive Oxygen Species are critical for epidermal architecture.

Figure 4:

(a) The ROS-scavenger N-acetylcysteine (NAC) or mitochondrial inhibitor dideoxycytidine (DDC) inhibit epidermal differentiation indicated by keratin-10 (red), filaggrin (green) and nuclei (blue). (b) Lysosomal inhibition diminished ROS, as demonstrated by the expression of NRF2 (red), with ColVII (green), and nuclei (blue). (c) Diffuse localization of cytochrome-c (red) in suprabasal layers of OTC reflects mitochondrial depolarization. All scale bars = 100μM.