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. 2019 Apr 10;54(6):2080–2094. doi: 10.3892/ijo.2019.4780

Figure 5.

Figure 5

Comparison of cytotoxic effects induced by both purified ZmPAO and BSAO in the presence of spermine on LoVo cells. LoVo WT (squares) and LoVo DX (circles) cells were incubated with ZmPAO (solid symbols) or BSAO (open symbols) in the presence of 12 µM spermine up to 60 min at 37°C. Each point represents the mean ± SEM of 2 independent experiments, with 2 to 5 plates per experiment. Where not visible, error bars are smaller than the symbols. Data are shown on a logarithmic scale. Data were analyzed by one-way ANOVA, followed by Tukey’s post hoc test. *P<0.05, **P<0.01, ***P<0.001 and ****P<0.0001 vs. LoVo WT cells incubated with ZmPAO and spermine; †P<0.05 vs. LoVo WT cells incubated with BSAO and spermine; ‡P<0.05, ‡‡P<0.01 and ‡‡‡P<0.001 vs. LoVo DX cells incubated with ZmPAO and spermine. ZmPAO, maize polyamine oxidase; BSAO, bovine serum amine oxidase; LoVo WT cells, LoVo wild-type cells; LoVo DX cells, LoVo multidrug-resistant cells.