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. 2019 Apr 9;54(6):1995–2004. doi: 10.3892/ijo.2019.4777

Figure 4.

Figure 4

Overexpression of TAZ inhibits the anticancer activities of HM. (A) Transfection efficiency of TAZ in MDA-MB-231 and MCF-7 cells was determined by western blotting. (B) Western blotting results of the TAZ-overexpression groups under HM treatment (50, 100 and 150 μM). (C) Overexpression of TAZ inhibited the HM-induced inhibition of proliferation. (D) Overexpression of TAZ inhibited the HM-induced inhibition of migration activity. (E) Overexpression of TAZ inhibited HM-induced apoptosis. Data are presented as the mean ± SD of three independent experiments. *P<0.05 and **P<0.01 vs. NC. TAZ, transcriptional co-activator with PDZ-binding motif; HM, harmine; NC, negative control (pCMV6-control).