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. 2019 May 16;14(5):e0216475. doi: 10.1371/journal.pone.0216475

Table 1. Representative studies for the tissue-specific combinatorial gene regulation based on TF cooperations.

Authors Synopsis of study Type of data
Ament et al. [7] Modeling of transcriptional network controlling mouse and human striatum as well as exploring the role of 48 TF-TF interactions in mouse models of Huntington’s disease RNA-seq and microarray gene expression data
Sonawane et al. [5] Investigation of cooperative TFs in regulatory networks for 38 human tissues RNA-seq data from the Genotype-Tissue Expression project
Zeidler et al. [8] Exploration of interacting TFs to understand the gene regulatory mechanisms during heart development RNA-seq time series dataset including five time points
Song et al. [9] Understanding and explanation of the role of 21 environmental stress related TF and their cooperativeness in the comprehensive regulatory network of Arabidopsis thaliana Chip-seq and RNA-seq data
Rhee et al. [10] Genome-wide analysis performed for Drosophila melanogaster in order to determine crucial biological functions of TF cooperations in tissue specification RNA-seq data of 29 tissues and developmental time points from the modENCODE project
Nandi et al. [11] Modeling of non-random functional dimers between the transcription factor MyoD and some muscle specific factors in the promoters of human genes Human promoter sequences from the DBTSSs [20]
Laresgoit et al. [12] Explanation of the essential role of the cooperation between transcription factors E2F2 and CREB for the regulation of transcriptional activity of cell cycle genes in mice Data from ChIP-chip experiments
Myšičková et al. [13] Systematic large-scale analysis for the characterization of tissue-specific TF interactions of 22 human tissues Expressed Sequence Tags (EST) data
Girgis et al. [21] Prediction of cis-regulatory motifs in 72 human tissues and identification of related TFs Expression data from GNF Atlas
Hu et al. [15] Systematic large-scale analysis for the identification of tissue-specific TF interactions for 79 human tissues Gene expression data from GNF Atlas2 gene expression database (gnfAtlas2) [22]
Yu et al. [14] Systematic large-scale analysis for the characterization of tissue-specific combinatorial gene regulation based on TF interactions for 30 human tissues Tissue-specific genes from NCBI EST database