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R167Q+/+ mice are runted. (A) Time course of body weight changes in R167Q+/+ male mice and sex-matched wild-type littermates. Data shown are means ± SDs (n = 7). P < 0.005 at all time points 2 weeks and beyond, Student’s t-test. (B) Representative image of a 1-year-old R167Q+/+ mouse (bottom) and wild-type littermate (top) shows that the R167Q+/+ mouse has a short body length and is also notably lean in comparison. WT, wild-type.
