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R167Q+/+ mice have progressive impairment of neuromotor function. Rotarod performance was assessed in R167Q+/+ and wild-type male mice at 2, 6, and 12 months, by placing them on a rotarod apparatus rotating at 16 rpm for a maximal time of 180 s. Data represent means ± SDs (n ≥ 6). *P < 5E-07, Student’s t-test.
