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. 2019 Jan 7;28(11):1755–1767. doi: 10.1093/hmg/ddz003

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R167Q^+/+ mice are not readily inducible by porphyrinognic factors. R167Q^+/+ and T1/T2 male mice were subjected to various porphyrinogenic stimuli, including fasting (Fa), pregnenolone-16α-carbonitrile (PCN; PC), phenobarbital (PB) and a combination of PB and 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) (PB/D), and (A) relative hepatic Alas1 mRNA and (B) plasma ALA and PBG concentrations were assessed. Baseline levels (BL) are shown for comparison. Data shown are means ± SDs (n ≥ 3).