Table 1. List of vIRF2-dependent cellular genes involved in defense response.
| Gene Symbol | Gene Description | Fold Change | |
|---|---|---|---|
| Exp. #1 | Exp. #2 | ||
| FGB | Fibrinogen beta chain | 32.0 | 57.5 |
| CLEC1B | C-type lectin domain family 1 member B | 31.1 | 30.8 |
| FGA | Fibrinogen alpha chain | 3.2 | 10.7 |
| UBD | Ubiquitin D | 8.5 | 4.3 |
| CLU | Clusterin | 3.9 | 5.0 |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | 3.3 | 5.5 |
| LYPD1 | LY6/PLAUR domain containing 1 | 3.0 | 5.7 |
| CD36 | CD36 molecule (thrombospondin receptor) | 3.9 | 3.6 |
| DEFB1 | Defensin beta 1 | 4.1 | 3.1 |
| CLEC1A | C-type lectin domain family 1 member A | 2.2 | 4.7 |
| CCL15 | Chemokine (C-C motif) ligand 15 | 3.9 | 3.2 |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 2.4 | 4.0 |
| PTGS1 | Prostaglandin-endoperoxide synthase 1 | 2.8 | 3.6 |
| LY75 | Lymphocyte antigen 75 | 2.8 | 3.3 |
| KALRN | Kalirin | 2.3 | 3.8 |
| TREM1 | Triggering receptor expressed on myeloid cells 1 | 3.2 | 2.7 |
| IL1A | Interleukin 1 alpha | 2.5 | 2.3 |
| IL1B | Interleukin 1 beta | 2.1 | 2.2 |
| HIST2H2BE | Histone H2B type 2-E | 2.3 | 2.2 |
| SERPING1 | Serpin peptidase inhibitor, clade G (C1 inhibitor) member 1 | 2.0 | 2.1 |
| DEF6 | Differentially expressed in FDCP 6 homolog (mouse) | -2.1 | -2.3 |
| TDGF1 | Teratocarcinoma-derived growth factor 1 | -2.3 | -2.1 |
| F3 | Coagulation factor III (thromboplastin, tissue factor) | -2.4 | -2.3 |
| C4BPB | Complement component 4 binding protein beta | -2.4 | -2.1 |
| CFH | Complement factor H | -2.3 | -2.3 |
| CXCL8 | Chemokine (C-X-C motif) ligand 8 | -2.2 | -2.4 |
| KCNN4 | Potassium intermediate/small conductance calcium-activated channel subfamily N member 4 | -2.5 | -2.4 |
| BMP6 | Bone morphogenetic protein 6 | -2.4 | -2.7 |
| VGF | VGF nerve growth factor inducible | -2.3 | -2.7 |
| ULBP1 | UL16 binding protein 1 | -2.5 | -2.5 |
| NLRP3 | NLR family, pyrin domain containing 3 (NLRP3) | -3.0 | -2.1 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | -2.3 | -3.0 |
| CCL20 | Chemokine (C-C motif) ligand 20 | -3.3 | -2.4 |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif 5 | -3.3 | -2.5 |
| IFIT1 | Interferon-induced protein with tetratricopeptide repeats 1 | -2.6 | -3.5 |
| NCF2 | Neutrophil cytosolic factor 2 | -3.9 | -2.3 |
| LOXL3 | Lysyl oxidase-like 3 | -3.7 | -2.7 |
| KLRC3 | Killer cell lectin-like receptor subfamily C member 3 | -3.0 | -3.9 |
| CAMP | Cathelicidin antimicrobial peptide | -3.1 | -4.1 |
| CXCL6 | Chemokine (C-X-C motif) ligand 6 | -4.2 | -3.1 |
| SLAMF7 | SLAM family member 7 | -2.9 | -4.4 |
| SIGLEC15 | Sialic acid binding Ig-like lectin 15 | -3.8 | -3.5 |
| IFIT3 | Interferon-induced protein with tetratricopeptide repeats 3 | -2.7 | -4.8 |
| IL33 | Interleukin 33 | -5.5 | -2.5 |
| CCR10 | Chemokine (C-C motif) receptor 10 | -5.3 | -2.9 |
| ZC3HAV1 | Zinc finger CCCH-type antiviral 1 | -3.8 | -4.6 |
| GGT5 | Gamma-glutamyltransferase 5 | -4.7 | -3.8 |
| OLR1 | Oxidized low density lipoprotein (lectin-like) receptor 1 | -5.2 | -5.1 |
| IFIT2 | Interferon-induced protein with tetratricopeptide repeats 2 | -5.7 | -6.5 |
| STATH | Statherin | -5.3 | -8.8 |
| CGA | Glycoprotein hormones, alpha polypeptide | -9.2 | -6.0 |
Cellular gene expression in KSHV.WT- vs. KSHV.ΔvIRF2-infected HuARLT cells undergoing lytic reactivation was measured by gene expression array. The values shown in the table represent ratios of intensity values (KSHV.ΔvIRF2-infected/KSHV.WT-infected) in lytically induced cells divided by the same ratio (KSHV.ΔvIRF2-infected/KSHV.WT-infected) in uninduced cells in two independent experiments. Negative values indicate genes that are upregulated by vIRF2, positive values those that are downregulated by vIRF2 in KSHV-infected cells.