Table 1.
Physicochemical Parameters for PABA/NO and Three Analogues
| compound | solubilitya (mM) | khydrolysisb (s−1) | kGSHc (M−1 s−1) | νC=O (cm−1) |
|---|---|---|---|---|
| 6a (PABA/NO) | <0.002 | (4.9 ± 2.4) × 10−4 d | 0.31 ± 0.02d | 1730 |
| 6b | >3 | ~0 | 0.043 ± 0.003 | 1685 |
| 6c | >2 | ~0 | 0.056 ± 0.003 | 1684 |
| 6d | 3 | ~0 | 0.13 ± 0.004 | 1685 |
a
Maximum solubility in 0.1 M phosphate buffer, 37 °C.
b
First-order rate constants for hydrolysis at pH 7.4 and, except as noted, 37 °C.
c
Secondorder rate constants for reaction with glutathione at pH 7.4 and, except as noted, 37 °C.
d
Rate data for PABA/NO were obtained at room temperature.