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Cytotoxic effect of Adriamycin (A), cisplatin (B), and TLK286 (C) on Adriamycin-sensitive (■) and resistant human leukemia cell lines (▲). Five × 103 cells/100 µl were dispensed into 96-well plates. After incubation for 72 h in the presence of indicated concentrations of Adriamycin, cisplatin, or TLK286, cell viability was determined using MTS reagents. Data are the mean of three experiments; bars, ±SD.
