Fig. 7.

In vitro activation of TLK286 via purified GSTπ. After a 0–2 h incubation, formation of the vinyl sulfone derivative (▲) compared with unchanged TLK286 (■) is represented by the percentage area under the curve (AUC).

In vitro activation of TLK286 via purified GSTπ. After a 0–2 h incubation, formation of the vinyl sulfone derivative (▲) compared with unchanged TLK286 (■) is represented by the percentage area under the curve (AUC).