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. Author manuscript; available in PMC: 2019 May 16.
Published in final edited form as: Drug Metab Dispos. 2003 Jun;31(6):705–713. doi: 10.1124/dmd.31.6.705

FIG. 2. HPLC elution profiles of cisplatin incubated for 30 min with GSH, Cys-Gly, or NAC.

FIG. 2.

Cisplatin was preincubated with equimolar GSH, Cys-Gly, or NAC in HBSS with 5 mM HEPES (pH 7.2) at 37°C for 30 min to allow for the spontaneous formation of cisplatin conjugates. Elution profiles of solutions containing cisplatin preincubated with GSH (A), Cys-Gly (B), or NAC (C) are shown. The elution time (min) of each of the peaks is noted.