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. Author manuscript; available in PMC: 2020 May 15.
Published in final edited form as: Cancer Res. 2019 Mar 26;79(10):2662–2668. doi: 10.1158/0008-5472.CAN-18-2460

Figure 3: Phospho-mimetic Dicer1 promotes tumorigenesis in p53+/−mice.

Figure 3:

A. Kaplan-Meier survival curve of p53+/− mice (n=19) and p53+/−; Dicer+/2SD mice (n=32) followed for 540 days. p=0.0855. B. Kaplan-Meier survival analysis of tumor-free survival of p53+/− mice (n=12) and p53+/−; Dicer+/2SD mice (n=21) followed for 540 days. p=0.0273. C. Tumor spectrum of p53+/− mice (n=3 cancers in 12 mice) and p53+/−; Dicer+/2SD mice (n=20 cancers in 21 mice). D. Frequencies of mice with cancer, multiple cancers, and disseminated cancers in p53+/−mice (n=12) and p53+/−; Dicer+/2SD mice (n=21). E. Representative immunofluorescence images of lymphomas and osteosarcomas captured at 63X displaying phosphorylated Dicer in green and DAPI in blue, in mice of the indicated genotypes. Scale bar: 50 microns.